At present, the most common genetic pathogenic loci include PMP22, GJB1, MFN2 and MPZ, and these account for more than 90% of all subtypes of the disease.[2] In recent years, with the development and application of gene sequencing technology, more than 90 pathogenic genes of other mutation sites and families have been discovered and reported.[3] However, to date, cases of SOD1 gene mutations in HMSN patients and families are rarely reported. This evidence concerns the gene SOD1 and hereditary motor and sensory neuropathy.