IL6 and infection: After IL-6 is synthesized in a local lesion in the initial stage of inflammation, it moves to the liver through the bloodstream, followed by the rapid induction of an extensive range of acute phase proteins, such as C-reactive protein, SAA, fibrinogen, haptoglobin, and a1-antichymotrypsin.[17] IL-6 is promptly and transiently produced in response to infections and tissue injuries, and contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions.