During tumor development, activated inflammatory cells act as donors of reactive oxygen species and reactive nitrogen mediators, resulting in DNA damage and genomic instability.[21] In return, DNA damage leads to an inflammatory response that promotes tumor progression.[22] SAA, as an acute-phase protein, activates its pathway and binds to plasma high-density lipoprotein in the presence of inflammation or tumor factors, playing a key role in the adhesion, invasion, and metastasis of tumor cells.[23] IL-6 is a pleiotropic inflammatory cytokine that plays conflicting roles in tumor cells. Here, IL6 is linked to neoplasm.