NOS3 and metabolic dysfunction-associated steatotic liver disease: It was reported that the higher the degree value of the target topology analysis, the better the connectivity of this type of targets and the regulation of the entire network.[67] Based on the principle, the proteins of HIF1A, NFE2L2, NOS3, NR3C1, PK3CA, and SIRT1 were considered to be the core targets of metformin for the treatment of NAFLD.