It was reported that the higher the degree value of the target topology analysis, the better the connectivity of this type of targets and the regulation of the entire network.[67] Based on the principle, the proteins of HIF1A, NFE2L2, NOS3, NR3C1, PK3CA, and SIRT1 were considered to be the core targets of metformin for the treatment of NAFLD. This evidence concerns the gene SIRT1 and metabolic dysfunction-associated steatotic liver disease.