CYP2E1 and metabolic dysfunction-associated steatotic liver disease: Previous studies have shown that obesity, insulin resistance (IR), dyslipidemia, abnormal glucose metabolism and hypertension are risk factors of NAFLD.[5] Liver lipid metabolism disorder, IR, the role of cytokines, increased expression of cytochrome P450 (CYP2E1, CYP4A), oxidative stress, lipid peroxidation, immune response, genetic factors and other related factors are all involved in the pathogenesis of NAFLD.[6] Therefore, improving IR and adjusting the balance of glucose and lipid metabolism may be an important measure for the prevention and treatment of NAFLD.