The NAFLD signaling pathways involved mainly including pathways in cancer, VEGF signaling pathway, non-alcoholic fatty liver disease (NAFLD), Hepatitis B, MAPK signaling pathway, regulation of lipolysis in adipocytes, FoxO signaling pathway, Hepatitis C, Osteoclast differentiation, Arginine and proline metabolism, Epstein-Barr virus infection, Proteoglycans in cancer, Toll-like receptor signaling pathway, Amoebiasis, T cell receptor signaling pathway, Type II diabetes mellitus, Estrogen signaling pathway, MicroRNAs in cancer, Prostate cancer, PI3K-Akt signaling pathway. This evidence concerns the gene PIK3CA and type 2 diabetes mellitus.