Additionally, the coagulation-fibrinolysis process has been identified at interconnecting with inflammatory cascade.[27] Therefore TXA could play a exert an anti-inflammatory effect by inhibiting plasmin-mediated activation of complement, monocytes, and neutrophils recruitment to the implanted biomaterials, which may consequently minimize postoperative pain.[28] Administration of TXA also helps to reduce postoperative pain by reducing intra-articular hemarthrosis.[29] But JW Wurtz et al suggested an opposing opinion about role of TXA reducing postoperative pain. Here, PLG is linked to hemarthrosis.