However, CRP levels are high in fewer than half of those with spondyloarthropathy.[24] Additionally, individuals with AS and IBP might take up to 10 years to show radiographic abnormalities.[25] Furthermore, according to the current National Institute for Health and Care Excellence guidelines, whole-spine radiography is not recommended for diagnosing low back pain.[26] Therefore, although almost half of the PCPs were aware of NSAIDs and the usefulness of physiotherapy, there was a lack of knowledge regarding the availability and usefulness of biological treatments for IBP. This evidence concerns the gene CRP and spondyloarthropathy.