P2RY12 and atrial fibrillation: In patients with AF and ACS or undergoing percutaneous coronary intervention (PCI), the current guidelines recommend the use of a short course (4–6 weeks) of triple therapy (dual antiplatelet therapy with aspirin and P2Y12 inhibitors plus an OAC) followed by dual therapy (P2Y12 inhibitor plus an oral OAC) for up to 12 months [13, 14].