For first time, this study describes that the minor allele T of rs2291007 in the FNIP2 gene is associated with metabolic and obesity-related phenotypes (elevated fat mass, visceral fatness, weight, BMI, and waist and hip circumferences) and with decreased muscle mass in healthy European individuals (Fig. 1A,B). Here, FNIP2 is linked to obesity due to melanocortin 4 receptor deficiency.