FNIP2 and obesity due to melanocortin 4 receptor deficiency: In summary, our genetic study on 48 loci revealed that minor allele T of rs2291007 in FNIP2 gene is linked to metabolic and obesity-related phenotypes, being associated with elevated fat mass, visceral fatness, weight, BMI, and waist and hip circumferences, and with decreased muscle mass in healthy individuals of European origin.