The top five hypermethylated lncRNAs (BVES-AS1, ZNF582-AS1, FGF14-AS2, NOVA1-AS1 and LIFR-AS1) and top five hypomethylated lncRNAs (AC017002.2, LINC00152, RP1-140K8.5, LINC00460 and RP11-474D1.4) in CRC are shown in Fig. 1D. This evidence concerns the gene POPDC1 and colorectal carcinoma.