Although population based data has previously shown that Pro-NT is more strongly associated with glucose regulation in Middle Easter immigrants than the native Swedish population, implying that neurotensin has a stronger negative influence on glucose regulation and development of diabetes and obesity in this immigrant population [19], this lifestyle intervention addressing overweight Middle Eastern immigrants did not have the power to show significant correlations between glucose regulation (assessed as fasting glucose and insulin sensitivity) with Pro-NT. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.