ERBB2 and gastroesophageal reflux disease: In our study, no significant association was found between HER2-overexpressed status and classical reported clinical, pathologic and prognostic factors (i.e. age, gender, family history, dietary and lifestyle habits (smoking, alcohol consumption, antioxidants, fatty foods and BMI), disease’s stages, GERD, Helicobacter pylori infections, pernicious anemia, presence of metastasis and treatment modalities).