On the other hand, the ability of curcumin to interact with miR-21, was found to play very important role in the pathogenesis of DN (Dey et al. 2011; Wang et al. 2014a, b, c; Zhong et al. 2013), probably, due to the miR-21’s involvement in the regulation of TGF-β-SMAD and PDCD4-JNK signaling pathways. This evidence concerns the gene MAPK8 and liver dysplastic nodule.