A specific pathological manifestation in patients suffering from DN was the induced macrophage production of inflammatory cytokines such as IL-1β, IL-6, IL-12, IL-18, TNF-α, IFN-γ, and MCP-1, (Hirata et al. 1998), (Wen et al. 2006) via NF-κB-dependent pathway that subsequently lead to albuminuria and renal fibrosis. The gene discussed is CCL2; the disease is renal fibrosis.