Thus, infiltrated macrophages in the inflamed kidney initiate production of profibrotic cytokines such as TGF-β, which play a key role in progressive renal fibrosis (Yang et al. 2007) In their studies, Park et al. (2000) and Kosugi et al. (2009) confirmed that ICAM-1, VCAM-1, and MCP-1 play a very important role in the pathogenesis of diabetic nephropathy by inducing inflammatory macrophage infiltration (Park et al. 2000), (Kosugi et al. 2009). This evidence concerns the gene CCL2 and diabetic kidney disease.