When combined with our previous data, which suggests that EFEMP2 facilitates the infiltration and migration of osteosarcoma cells through its activation of the PI3K/Akt/mTOR signaling pathway,24 we suggest that STEAP2 is a likely effector in this process, acting as a critical conduit for proliferation, infiltration, and EMT. This evidence concerns the gene EFEMP2 and osteosarcoma.