EMT is known to be critical to the malignant progression of tumors and is characterized by the movement of epithelial cells from the underlying basement membrane into the tumor microenvironment and their subsequent acquisition of the mesenchymal phenotype, resulting in increased migratory and invasive capacity.25 Here, we describe the crucial function of STEAP2 in osteosarcoma cell infiltration and migration, which in turn led us to speculate that the differential regulation of STEAP2 might affect the EMT process. Here, STEAP2 is linked to neoplasm.