HEPHL1 and Hand-foot syndrome: In addition, we found some differential RESs edited genes function in skin development, hair growth, and HFs cycle have been reported, such as APCDD1, WWOX, MPZL3, RUNX1, KANK2, DCN, DSC2, LEPR, and HEPHL1. Previous studies revealed that the mutation of APCDD1 was associated with hair loss in hereditary hypotrichosis simplex patient, and suggested APCDD1 as an inhibitor of WNT pathway may cause HFs miniaturization and hair loss [44].