In addition, we found a significant positive correlation between the levels of CD28−CD57+CD8+ T-cells and levels of sCD14 (r = 0.3, p = 0.012), Together, these results suggest that higher levels of senescent CD28−CD57+CD8+ T-cells may be attributed to microbial translocation in severe periodontitis. The gene discussed is CD8A; the disease is periodontitis.