ATG16L1 and neoplasm: The results are shown in Fig. 7A. The injection of NOD2 overexpression lentivirus into the mass successfully increased the expression level of NOD2, increased the protein expression of P-ATG16L1 and LC3II, and reduced the protein content of P62, indicating that the overexpression of NOD2 increased the autophagy level of tumor tissue in vivo.