Other cellular and molecular factors involved in the cross-talk between DM and AD are oxidative stress, obesity, inflammation, dysregulation of Apolipoprotein E (APOE), Insulin Degradation Enzyme (IDE), Glucose Transporter type 4 (GLUT4), and Acetylcholinesterase (AChE)4. This evidence concerns the gene APOE and obesity due to melanocortin 4 receptor deficiency.