CASP1 and brain disorder: To better understand the effect of SARS-CoV-2 infection on promoting human microglia activation in relation to brain disease triggers, MDMi were incubated with Wu (MOI 0.1 or 1) in the presence or absence of preformed fibrils of α-synuclein for 24 h as shown in a schematic representation in Fig. 6A, and the level of cleaved IL-1β, cleaved caspase-1 and ASC in the supernatant were measured by western blot.