Analysis of differential metabolites between vH6 and HCD_ND groups revealed that vH6 regulated hypercholesterolemia in mice by many pathways, including vitamin digestion and absorption, lipolysis regulation, cAMP signaling pathway, linoleic acid metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, mTOR signaling pathway, PI3K-Akt signaling pathway, and secondary bile acid biosynthesis. Here, MTOR is linked to Hypercholesterolemia.