Further analysis of Pearson correlations between gut microbiota (top 10 genera at the genus level) and physicochemical indicators of hypercholesterolemia showed that norank_f__Muribaculaceae and Lactobacillus had significant negative correlations with TC, TG, LDL, ALT, AST, and liver weight. The gene discussed is GPT; the disease is familial hypercholesterolemia.