CD4 and tuberculosis: Different factors contributed to the existence of TF like patients who didn’t change ART regimens, poor medication adherence, not taking Isoniazid (INH) prophylactic therapy, being on Zidovudine (AZT) based regimen, having lower baseline CD4 count, being bedridden during ART initiation, older age, Presence of WHO disease stage III/IV, history of injection drug use, previous protease inhibitor use, being on a second-line ART regimen, TB co-infection10–15.