Previous studies have comprehensively studied the specific methylation profiles associated with AML cases carrying different mutations; while mutations in DNMT3A may lead to DNA hypomethylation, those in IDH1/2 or TET2 result in different degrees of DNA hypermethylation due to loss of the demethylating function of TET proteins or just TET2, respectively1,2,5. This evidence concerns the gene IDH1 and acute myeloid leukemia.