DNMT3A and acute myeloid leukemia: To determine whether the high methylation-expression correlation of these genes was specific to AMLs with IDH1/2 or DNMT3A mutations, we performed correlation analysis on the same gene-mCpG pairs in AML samples without mutations in IDH1/2 or DNMT3A. We compared the correlation coefficients of these gene-mCpG pairs in the DNMT3A/IDH1/2 samples with the ones in the WT/WT samples and found that these coefficients were significantly lower in the WT/WT samples in both cohorts (p value < 10−4; Supplementary Fig. 1h).