DNMT3A and acute myeloid leukemia: Previous studies have comprehensively studied the specific methylation profiles associated with AML cases carrying different mutations; while mutations in DNMT3A may lead to DNA hypomethylation, those in IDH1/2 or TET2 result in different degrees of DNA hypermethylation due to loss of the demethylating function of TET proteins or just TET2, respectively1,2,5.