Knockdown of DNAJA1 triggers CHIP/STUB1 ubiquitin ligase-mediated proteasomal degradation of mutp53, leading to reduced malignant properties of cancer cells; however, knockdown of DNAJA1 has little effect on the levels of wild-type p53 (wtp53) and DNA-contact mutp53 [17, 18]. Here, STUB1 is linked to cancer.