DNAJA1 enhances formation of aggregation of polyQ74htt in the Huntington’s disease model [34, 35], reduces aggregation of neurodegenerative disorder-associated tau [36], and promotes folding of newly synthesized cystic fibrosis transmembrane conductance regulator at the endoplasmic reticulum [37–39]. The gene discussed is DNAJA1; the disease is Huntington disease.