STX2 and type 2 diabetes mellitus: Thus, in spite of greatly reduced levels of profusion SNARE proteins in T2D β-cells40,41, Stx2 depletion must still be able to facilitate sufficient SNARE complex assembly and disassembly to replenish enough component SNAREs for repeated rounds of SNARE complex formation, to enable the rescue and sustenance of biphasic GSIS in diabetic islets.