CASP3 and Huntington disease: In contrast to the effects of a single agent, G-1/VEN combination significantly reduced cell viability (combination index [CI], 0.36–0.49; Fig. 3A–C), increased cell apoptosis rate (Fig. 3D–F), upregulated the levels of cell apoptosis-related proteins BAX and cleaved CASP-3, but downregulated those of CASP-3 (Fig. 3G), while had little effect on PBMNCs from HD (Fig. S3A, B).