Thus, tFNA-RNase A complexes can enter cells via endocytosis and successfully release RNase A, degrading cellular RNA to induce cancer cell apoptosis.141 Furthermore, a dynamic and active targeting tFNA was designed and developed by Tian et al. to deliver melittin.142 The tFNA-melittin complex, also named nanobee, could selectively release melittin from the tFNA structure once it underwent a conformational change stimulated by its target proteins on the cell membrane. Here, RNASE1 is linked to cancer.