Accordingly, increasing AEA/NAE availability by application of selective FAAH inhibitor PF3845 (Ahn et al., 2009) suppressed BCC-induced network hyperexcitation in a dose-dependent manner, resulting in lowered mean firing rate, burst frequency and network burst frequency comparing to BCC only treatment (Fig. 4C, *p < 0.05, $p < 0.05). This evidence concerns the gene FAAH and skin basal cell carcinoma.