We confirmed this finding by treating neurons with a cocktail of 1 μm MTEP and 100 nm JNJ16259685 (MTEP/JNJ), noncompetitive inhibitors of mGluR5 and mGluR1, respectively, and showing that this treatment prevented BCC-induced downregulation of surface GluA1 and partially blocked the dephosphorylation of pS845 (Fig. 3B). The gene discussed is GRM1; the disease is skin basal cell carcinoma.