Furthermore, all genes validated from our screen had an impact on seeded tau aggregation initiated by both vesicle-free and exosomal tau seeds, implying that therapeutically targeting our protein hits would not render neurons exposed to the attack of either free or membrane-bound tau but holistically cover both entry routes (Polanco & Götz, 2021), thereby representing a more efficacious and unifying treatment strategy for tauopathies. Here, MAPT is linked to tauopathy.