Interestingly, anomalous invaginations of the nuclear envelope have been found in AD and FTLD-tau patients (Paonessa et al, 2019; Kang et al, 2021), and tau accumulates close to these invaginations (Paonessa et al, 2019), with evidence suggesting that liquid-liquid phase separation of tau at the nuclear envelope might be a possible initiating event in tauopathies (Kang et al, 2021). The gene discussed is MAPT; the disease is Alzheimer disease.