Furthermore, using the same dataset Sturchio et al. [11] demonstrated that in the models adjusted for age, sex, education, APOE4, p-tau levels, and t-tau levels, lower CSF-Aβ42 levels are associated with a higher probability of AD and worse cognitive status, as well as various other indices of the disease even when the comparison was made between groups with the same brain amyloid load. This evidence concerns the gene MAPT and Alzheimer disease.