One patient with Waldenstrom’s disease had bilateral macular involvement in form of subfoveal defects of the retinal pigment epithelium with cystoid macular edema and one patient with SMM type IgA λ had macular involvement in form of a focal detachment of the neurosensory retina with secondary choroidal neovascularization (CNV). This evidence concerns the gene CD79A and cystoid macular edema.