Exome sequencing of meningiomas and matching blood samples [56–58] has identified a plethora of recurrent SSVs ranging from common to rare in the following genes: NF2, KLF4, TRAF7, PIK3CA, AKT, SMO, SUFU, POLR2A, SMARCB1, SMARCE1, TERT [59] (promoter), BAP1 [60], DMD [61], ARID1A, and CDKN2A/B [62] (heterozygous or homozygous deletion). The gene discussed is PIK3CA; the disease is meningioma.