The interaction between phagocyte pattern recognition receptors (PRRs) and Mtb antigens triggers the production of various proinflammatory cytokines, including interleukin-12 (IL-12), tumor necrosis factor-α (TNF-α), IL-1β and IL-6, as well as chemokines that recruit and activate other innate and adaptive immune cells from the circulation to the site of infection. The gene discussed is TNF; the disease is infection.