Moreover, to monitor the progress of the disease, the antibody response is evaluated by detecting immunoglobulin M (IgM; the first Ig type through which the immune system responds to antigens, in a matter of days) and immunoglobulin G (IgG; Ig that replaces IgM as the immune response matures a couple of weeks after infection) specific for said viral antigens (19, 20). This evidence concerns the gene CD40LG and infection.