IFNA1 and hepatocellular carcinoma: However, when focusing on the cross talk between IFIT3 and HBV infection, just one study reported that IFIT3 could be induced by HBx in an NF-κB-dependent manner, leading to enhanced HBV replication (24), while another study suggested that IFIT3 promotes IFN-α effector responses and therapeutic effects on HCC (25).