The SARS-CoV-2 infection was inhibited by an anti-human ACE2 (hACE2) monoclonal antibody (AC384) in a dose-dependent manner (Fig. 1D and Fig. S2B), strongly suggesting that the infection of the two spheroids by SARS-CoV-2 was mediated by ACE2 expressed on those cells. This evidence concerns the gene ACE2 and infection.