ABCC8 and hypertensive disorder: After adjusting linear regression models for confounding factors (age, sex, hyperlipidaemia, hypertension, BMI and CKD stage), we observed that CCIMT median values were higher in carriers of two SNPs in ABCC8, rs3758953 and rs2188966, compared with wild-type subjects [0.78 (0.25) vs. 0.72 (0.22) mm, p < 0.05 and 0.79 (0.26) vs. 0.72 (0.22) mm, p < 0.05, respectively] (Figure 2 and Supplementary Table S4).