In addition, when we examined the antigen-nonspecific CD8+ T cell response, interferon-gamma positive (IFN-γ+) CD8+ T cells were increased in intravenously inoculated CMs and in CMs preadministered an anti-CD8 MAb after the inoculation of cells compared to the levels before infection (Fig. 8). The gene discussed is CD8A; the disease is infection.