To evaluate this, we used peripheral blood mononuclear cells (PBMCs) from CMV, EBV, and/or VZV latently infected children (age 1 to 17 years), with or without pediatric rheumatic diseases (PRD), to assess circulating memory T cell subsets ex vivo and the numbers of IFN-γ-, interleukin 10 (IL-10)-, IL-17A-, and IL-22-producing cells after in vitro stimulation with CMV, EBV, or VZV. The gene discussed is IL10; the disease is rheumatic disorder.