The HSV-1 pUL36 DUB and its homologs in other herpesviruses fulfil a variety of different functions that range from antagonizing the innate immune and DNA damage responses, facilitating appropriate intracellular capsid motility and tegument assembly, and augmenting infection both in vitro and in vivo (41, 43, –, 53). Here, ZUP1 is linked to infection.