ZUP1 and infection: In fact, Horan et al. show that the major capsid protein VP5 is ubiquitinated in macrophages (78), although the list of ubiquitinated HSV-1 proteins also includes pUL36, pUL37, pUL25, and pUL6, which were found to be more ubiquitinated in infections with a HSV-1 pUL36 DUB mutant (42).