Additionally, we detected the presence of transcription regulators such as SAFB1, DDX3X, and SIR2 from all DARPin complexes, and additional transcription factors, including MECP2 (a Rett syndrome-associated protein regulating inhibitory network development [Pelkey et al., 2017] and present at the PSD [Aber et al., 2003]) found only in 27B3 and 27G2 gephyrin complexes. Here, GPHN is linked to atypical Rett syndrome.