Microglia activation in juvenile (Figure 2) and adult (Figure 1) STING ki mice is therefore in line with the increased inflammatory phenotype found in the lungs and spleen of STING ki mice (Luksch et al., 2019; Siedel et al., 2020) and in patients with STING-associated vasculopathy with onset in infancy syndrome (Liu et al., 2014). Here, STING1 is linked to vascular disorder.