Plasma IL-35 level in PBC patients did not correlate with CD3+ T cell count (r ═ –0.226, P ═ 0.111, Figure 2D), CD4+ T cell count (r ═ –0.138, P ═ 0.333, Figure 2E), or CD8+ T cell count (r ═ –0.039, P ═ 0.785, Figure 2F). This evidence concerns the gene CD8A and primary biliary cholangitis.