Exogenous IL-35 stimulation reduced RORγt mRNA relative level (3.28 [IQR 2.09, 5.06] vs 4.36 [IQR 2.49, 6.83]; P ═ 0.034, Figure 5C) and IL-17 production (59.00 [IQR 50.43, 96.23] pg/mL vs 66.58 [IQR 55.85, 104.8] pg/mL; P ═ 0.0098, Figure 5G) in CD4+ T cells from PBC patients. This evidence concerns the gene CD4 and primary biliary cholangitis.