So far, mutations in genes that encode RNA‐binding proteins (RBPs), including FUS, TDP‐43, hnRNPA1, hnRNPA2B1, MATRIN3, TAF15, and TIA1, are being recognized as causal drivers or associated with multiple neurodegenerative diseases, such as ALS, multisystem proteinopathy, and frontotemporal dementia.14, 15. The gene discussed is HNRNPA1; the disease is amyotrophic lateral sclerosis.