CD8A and generalized anxiety disorder: Such microglial nodules also revealed nuclear upregulation of pSTAT-1, indicating type I interferon signalling which may represent a possible therapeutic target.48 These characteristic findings equal those in CD8-mediated animal models49,50 and their human counterparts RE and paraneoplastic cerebellar neurodegeneration.17,48,50 The time until resolution of the early/active phase (estimated by density of the brain-infiltrating T cells) is approximately five times longer in GAD-TLE compared with RE.51