CPSF6 and infection: Here, we provide new insights on the properties of CPSF6 protein clusters induced by the infection, and we unravel their unexpected role in HIV-1 pre-integration steps in non-dividing cells, known to be an important cellular reservoir (Ganor et al., 2019; Kruize and Kootstra, 2019; Real and Bomsel, 2019; Veenhuis et al., 2021).