In addition to exhibiting psoriasis-like features, Asian AD patients often show a robust Th17 response (IL-17A, IL-19 and S100A12) in the skin lesions (129) and are more susceptible to S. aureus colonization, perhaps due to a lack of AMPs, damage to the skin barrier and dysbiosis of the microbial ecology. The gene discussed is IL17A; the disease is Alzheimer disease.