Change in KSQ, 6MWD Change in serum CBC, Vit D, sACE, CRP and several other biomarkers Change in PET/CT and bone density scores Not stated. HRQoL (Treatment satisfaction QoL) measures, change in PDDS, MoCA, SF-36 and Beck depression Inventory-11. The gene discussed is CRP; the disease is depressive symptom measurement.