CXCR5+CD8 T cells have slowly come into focus with their unique ability to provide B cell help within germinal centers similar to CD4 Tfh and also maintain a cytolytic capacity in infection, autoimmunity and tumor microenvironments resembling CD8 T effector cells (Figure 1) (1–5, 10, 11). The gene discussed is CXCR5; the disease is neoplasm.