In H. pylori-infected GC, a decreased expression of TNF-α, IL-1β, and IL-8 was detected after knockdown of plasmacytoma variant translocation 1 (lncPVT1) and the migration of GC cells was inhibited, suggesting that lncPVT1 might activate immune function to affect GC caused by H. pylori (77). This evidence concerns the gene TNF and gastric cancer.