The decrease of miR-204 level induced by H. pylori infection could up-regulate the downstream target gene BIRC2, enhance the activity of BIRC2/TNF-α/NF-κB signaling pathway, thus promote angiogenesis and metastasis of GC cells, leading to poor prognosis of H. pylori-related GC patients (58). Here, NFKB1 is linked to gastric cancer.