FBXW4 and kidney disorder: Although there was no evidence that the MDFI and FBXW4 genes are associated with kidney disease, MDFI can regulate the WNT signaling pathway, which is essential for the development of the mammalian kidney (43), and it was a cysteine rich glycoprotein in the extracellular matrix and played a key role in embryonic development and adult tissue homeostasis (44), Wnt/ β- Catenin signal was involved in the regulation of glomerulosclerosis and podocyte dysfunction, it was related to renal fibrosis.