Then, we selected common genes from the three algorithms which were the hub genes MDFI, EHBP1L1, FBXW4, MDM4, RALYL, and ESM1. The AUC of these genes ranged from 0.872 to 0.974, indicating a high level of predictive power for AKI, and the AUC of the nomogram was 1, we also used the bootstrap algorithm to estimate the 95% AUC confidence intervals. Here, EHBP1L1 is linked to acute kidney injury.