UGT1A1 and Hyperbilirubinemia: Additional risk factors for the development of significant hyperbilirubinemia in low to middle income countries include maternal factors (primiparous, delivery outside the hospital) and neonatal factors (lower gestational age and birth weight, UDP glucuronosyltransferase 1 family, polypeptide A cluster (UGT1A) polymorphisms and sepsis) (7).