IL10 and obesity due to melanocortin 4 receptor deficiency: In visWAT, IL10 did not correlate with HOMA-IR neither in men nor in women (Supplementary Figure S2), whereas scWAT IL-10 had a trend towards a positive correlation (p=0.096) in women and but not in men (Supplementary Figure S2) indicating that the sex specific regulation of IL-10 in obesity/T2D is only attributed to scWAT.